California Polytechnic State University-San Luis Obispo to The Fashion Institute of Design & Merchandising-Los Angeles buses and trains from $29

Here are some trips other travelers have found on Routefriend.
$29
4h 34m
0 stops
Greyhound
$34
5h 19m
0 stops
Amtrak
$41
5h 55m
1 stop
Amtrak