Detroit, MI to University of Pennsylvania buses and trains from $92

Or, see buses and trains from University of Pennsylvania to Detroit, MI.
Here are some trips other travelers have found on Routefriend.
$92
17h 10m
2 stops
Amtrak
$133
15h 30m
2 stops
Greyhound
$144
19h 0m
2 stops
Greyhound Amtrak