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Loyola College in Maryland to University of South Carolina-Columbia buses and trains from $45
Here are some trips other travelers have found on Routefriend.
$45
13h 34m
1 stop
 Amtrak Megabus
$67
13h 0m
1 stop
 Amtrak Megabus
$96
11h 49m
0 stops
 Amtrak
$195
18h 15m
1 stop
 Amtrak Amtrak