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San Luis Obispo, CA to The Fashion Institute of Design & Merchandising-Los Angeles buses and trains from $29
Here are some trips other travelers have found on Routefriend.
$29
4h 35m
0 stops
 Greyhound
$34
5h 20m
0 stops
 Amtrak
$41
5h 54m
1 stop
 Amtrak