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Seattle University to University of Detroit Mercy buses and trains from $214
Here are some trips other travelers have found on Routefriend.
$214
2d 3h
3 stops
 Greyhound
$250
2d 12h
4 stops
 Amtrak Greyhound
$291
2d 6h
2 stops
 Greyhound Amtrak
$305
2d 4h
1 stop
 Amtrak