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The Fashion Institute of Design & Merchandising-Los Angeles to California Polytechnic State University-San Luis Obispo buses and trains from $32
Here are some trips other travelers have found on Routefriend.
$32
4h 20m
0 stops
 Greyhound
$34
4h 50m
0 stops
 Amtrak
$41
5h 5m
1 stop
 Amtrak
$51
13h 0m
2 stops
 GotoBus Amtrak
$67
7h 45m
2 stops
 GotoBus Amtrak